Kansas City Chiefs at San Francisco 49ers 10/23/22 - NFL Picks & Predictions

The Kansas City Chiefs visit Levi’s Stadium on Sunday to play the San Francisco 49ers. Kansas City is 4-2 following its 24-20 loss to the Buffalo Bills on Sunday afternoon. Kansas City gained 387 yards of total offense but committed a pair of costly turnovers, while allowing Buffalo to gain 443 yards of total offense. Patrick Mahomes passed for 338 yards with two touchdowns but was intercepted twice.

Kansas City quarterback Patrick Mahomes has passed for 1,736 yards with 17 touchdowns and four interceptions. Clyde Edwards-Helaire is the leading rusher with 256 yards and two touchdowns, while the leading receiver is Travis Kelce with 455 yards and seven touchdown receptions. On defense, linebacker Nick Bolton is the leading tackler with 60. Kansas City has 14 quarterback sacks and one interception.

San Francisco is 3-3 following its 28-14 loss to the Atlanta Falcons on Sunday. San Francisco gained 346 yards of total offense but the 49ers committed three costly turnovers, one of which was a fumble in the end zone that resulted in a touchdown for Atlanta. San Francisco quarterback Jimmy Garoppolo passed for 296 yards with two touchdowns but was intercepted twice. 

Quarterback Jimmy Garoppolo has passed for 1,153 yards with seven touchdowns and three interceptions. The leading rusher is Jeff Wilson Jr. with 400 yards and two touchdowns, while the leading receiver is Deebo Samuel with 345 yards and two touchdown receptions. On defense, linebacker Dre Greenlaw is the leading tackler with 55. San Francisco has 23 quarterback sacks and five interceptions.