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Indianapolis Colts
San Francisco 49ers

Indianapolis Colts at San Francisco 49ers 10/24/21 - NFL Picks & Predictions

San Francisco 49ers vs Indianapolis Colts Odds & Info

Game San Francisco 49ers vs Indianapolis Colts
Date & Time Sunday October 24, 2021, 8:20 PM (EDT)
Levi's Stadium Levi's Stadium, Santa Clara, USA
Latest odds
SF -3.5 ; O/U 45
TV Channel

The Indianapolis Colts roll into San Francisco for Sunday night football to take on the 49ers. The Colts are coming off an impressive win last week when they beat the Texans 31-3. Carson Wentz threw for 223 yards and 2 touchdowns. Wentz now has 9 touchdowns passes on the season with just 1 interception. 

The Colts are 2-4 on the season with a 1-2 road record. Indianapolis has been balanced on both sides of the ball thus far. The Colts average 124.2 rushing yards per game which ranks 11th in the NFL. Running back Johnathan Taylor has 87 carries on the year with 472 yards and 4 touchdowns. 

The San Francisco 49ers roll back to their home field riding a three game losing streak. The 49ers lost at Arizona last week 17-10. Trey Lance went 15/29 with 1 interception. Lance did not throw for a touchdown in the loss but did rush for 89 yards. Deebo Smith leads the team with 31 receptions for 548 yards and 3 touchdowns. 

The 49ers started the season with a two game win streak but are now 2-3 on the year. San Francisco is seeking their first win at home. The 49ers are the 8th best defense allowing 348.6 yards per game. San Francisco last played the Colts back in 2017 when they lost 26-23. 

Recent Betting Trends

  • Road team is 4-1 ATS in their last 5 meetings.
  • Colts are 7-2 ATS in their last 9 road games.
  • Colts are 6-2 ATS in their last 8 games in Week 7.
  • 49ers are 3-12-1 ATS in their last 16 games in Week 7.

Free NFL Pick:

Indianapolis Colts +3.5

The Indianapolis Colts show value as a road underdog on Sunday night. The Colts are getting more than a field goal and have a great shot of winning this game outright. The 49ers have fell apart over the last three week and will have another tough game in this spot. The Colts are 2-0 against the spread on the road this season. Final Score Prediction, Indianapolis Colts win and cover ATS 34-31.

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