Houston Texans at San Francisco 49ers 1/2/22 - NFL Picks & Predictions

Last Updated: 12/27/2021 at 2:04 PM ET

Houston Texans at San Francisco 49ers 1/2/22 - NFL Picks & Predictions

On Sunday, the Houston Texans visit Levi's Stadium in Santa Clara, California to play the San Francisco 49ers. Houston improved to 4-11 following a 41-29 victory over the Los Angeles Chargers and in the process hurt the Chargers opportunity to reach the postseason. Houston’s Davis Mills passed for 254 yards and two touchdowns and Rex Burkhead rushed for 149 yards and two touchdowns.

Davis Mills has passed for 2,200 yards with 12 touchdowns and nine interceptions. The leading rusher for Houston is Rex Burkhead with 356 yards and three touchdowns while the leading receiver is Brandin Cooks with 945 yards and five touchdown receptions. On defense, Kamu Grugier-Hill is the leading tackler with 94 and Jonathan Greenard is the leader in quarterback sacks with 8.0.

San Francisco dropped to 8-7 following a 20-17 loss on Thursday Night Football to the Tennessee Titans. San Francisco remains in the playoff hunt in the NFC and is currently sixth, which is one game behind the Arizona Cardinals with two games remaining, with the top seven advancing. In Thursday's loss to Tennessee, Jimmy Garoppolo passed for 322 yards and one touchdown while being intercepted twice. San Francisco tied the score with just over two minutes remaining to play but gave up a winning field goal with four seconds to play.

Jimmy Garoppolo has passed for 3,494 yards with 19 touchdowns and 10 interceptions. The leading rusher is Deebo Samuel with 301 yards and seven touchdowns, while the leading receiver is Samuel with 1,247 yards and five touchdown receptions. On defense, Fred Warner is the leading tackler with 114 and Nick Bosa is the leader in quarterback sacks with 15.0.

San Francisco needs a victory to keep its playoff hopes alive and will be playing at home. Houston is eliminated from playoff contention but the Texans played spoiler this past Sunday by defeating the Los Angeles Chargers and look to do the same against the 49ers on the road. However, the Texans have failed to cover the number in each of the last four head-to-head versus San Francisco. Final Score Prediction, San Francisco 49ers win and cover ATS 31-10.

Download the Picks and Parlays Mobile App

Get A free VIP Pick Daily!