Detroit Lions at Arizona Cardinals 9/27/20 - NFL Picks & Predictions

Last Updated: 09/21/2020 at 12:06 PM ET

The Detroit Lions visit State Farm Stadium in Glendale, Arizona on Sunday to play the Arizona Cardinals.The Detroit Lions dropped to 0-2 following a 42-21 loss to the Green Bay Packers on the road Sunday. The Detroit defense has given up 69 points in the first two games. Detroit at one time led 14-3 during the first half before Green Bay rallied to the victory. It was the fourth straight game that the Lions have held a lead of double digits and eventually lost and Detroit is the first NFL team to accomplish that dubious feat.

Matthew Stafford has thrown for 541 yards, three touchdowns, two interceptions and has been sacked five times. The leading rusher for Detroit is Adrian Peterson with 134 yards. TJ Hockenson is the leading receiver with 118 yards and one touchdown, while Danny Amendola has 102 yards receiving. On defense, safety Tracy Walker is the leading tackler with 11.

Arizona improved to 2-0 following its 30-15 victor over the Washington Football Team on Sunday. Cardinals quarterback Kyler Murray scored a pair of touchdowns on the ground to lead Arizona to the victory. Murray rushed for 67 yards and the offense played well enough to defeat Washington. On Sunday, Arizona also sacked Washington’s quarterback four times as it's defense came up big against the Washington offense.

Kyler Murray has thrown for 516 yards, two touchdowns, two interceptions and has been sacked five times. Murray is also the leading rusher with 158 yards and three touchdowns while running back Kenyan Drake has rushed for 146 yards and one touchdown. DeAndre Hopkins is the leading receiver for Arizona with 219 yards and one touchdown. On defense, safety Budda Baker is the leading tackler for Arizona with 20.

Detroit's woes will continue on the road Sunday in Arizona. The Lions have one of the worst defenses in the NFL and are allowing an average of 34.5 points per game through the first two games of the season. Detroit has failed to cover the number in seven of its last eight played in Arizona and five of its last seven overall against the Cardinals. Playing at home helps in this matchup, as the home team (Arizona) has covered the number and 12 of the last fourteen meetings. Final Score Prediction, Arizona Cardinals win and cover ATS 34-21.

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