Broncos vs Bills Picks and Prediction – 1/12/2025

The Denver Broncos visit Highmark Stadium in Orchard Park, New York on Sunday to play the Buffalo Bills in an AFC wild-card game. Denver completed the regular season 10-7 and was third in the AFC West. The Broncos won the final game of the regular season 38-0 over Kansas City to qualify for the postseason. Denver lost two of its final three games. Keep up to date with all the NFL action, with our expert NFL picks.

During the regular season, Denver quarterback Bo Nix threw for 3,775 yards with 29 touchdowns and 12 interceptions. Nix was sacked 24 times and 17 games. Javonte Williams was the leading rusher for Denver with 513 yards and four touchdowns. Courtland Sutton was the leading receiver with 1,081 yards and eight touchdown receptions. Denver's defense made 63 quarterback sacks and intercepted 15 passes.

The Buffalo Bills completed the regular season 13-4 and won the AFC East. Buffalo finished second in the AFC behind Kansas City. Buffalo lost its final game of the regular season 23-16 to the New England Patriots, which snapped a three-game winning streak for Buffalo. However, Buffalo had already locked into the No. 2 seed in the AFC and was able to rest its starters for this week.

During the regular season, Buffalo quarterback Josh Allen threw for 3,731 yards with 28 touchdowns and six interceptions. Allen was sacked only 14 times and seven games. Allen rushed for 531 yards and 12 touchdowns. The leading rusher was James Cook with 109 yards and 16 touchdowns. Khalil Shakir was the leading receiver with 821 yards and four touchdown receptions. Buffalo’s defense made 39 quarterback sacks and intercepted 16 passes.

The Buffalo Bills will win on Sunday when hosting the Denver Broncos but will fall short against the number. Buffalo is only 5-3 ATS over the last eight, while Denver has covered the number in six of the last eight. Denver's defense, which held opponents to 19.4 points per game, will keep this matchup close enough throughout to cover in the end but fall short straight up. Buffalo’s offense and defense will be too much for the Broncos to win SU. Final Score Prediction, Buffalo Bills win but fall short ATS 27-24.