Colts at Titans 9/15/19 - NFL Picks & Predictions

Last Updated: 09/11/2019 at 1:55 PM ET

AFC South Division rivals will clash on Sunday afternoon, when the Indianapolis Colts travel to Nissan Stadium to tackle the Tennessee Titans. The Colts were a popular Super Bowl pick, but suffered a major loss when QB Andrew Luck decided to retire. In week one, Indianapolis rallied to force overtime before falling at Los Angeles by a 30-24 final score. T.Y. Hilton caught eight passes for 87 yards and two touchdowns for the Colts.

Indianapolis dominated the ground game and finished with 203 yards on 33 attempts. Marlon Mack rushed for 174 yards and a touchdown on the afternoon.

The Tennessee Titans were the only AFC South team to win their season opener and did it in impressive fashion with a 43-13 road triumph against Cleveland. The Colts led by two late in the third quarter before exploding to score the final 28 points of the game. Marcus Mariota completed 14 of his 24 passing attempts for 248 yards and three touchdowns. 

The Titans took advantage of 18 penalties for 182 yards by the Browns and limited them to 1-for-10 on third downs. Malcolm Butler put the icing on the cake with a 38-yard interception return for a touchdown.

Indianapolis WR Devin Funchess (collarbone) has been placed on injured reserve and is not eligible to return until week 10. The Colts showed plenty of heart during their week one loss and are a solid underdog play in this matchup. Take Indianapolis to score the upset. Final Score Prediction, Indianapolis Colts win and cover ATS 24-21.

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