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Buffalo Bills
New Orleans Saints

Buffalo Bills at New Orleans Saints 11/25/21 - NFL Picks & Predictions

New Orleans Saints vs Buffalo Bills Odds & Info

Game New Orleans Saints vs Buffalo Bills
Date & Time Thursday November 25, 2021, 8:20 PM (EST)
Mercedes-Benz Superdome, New Orleans, LA
Latest odds
BUF -4 ; O/U 46.5
TV Channel

The Buffalo Bills visit Caesars Superdome in New Orleans, Louisiana on Thanksgiving Night to play the New Orleans Saints.  Buffalo is 6-4 and second in the AFC East, a half-game behind New England following a 41-15 loss to the Indianapolis Colts on Sunday. Buffalo gained 307 yards of total offense and committed four turnovers, The Bills defense gave up 185 yards rushing to Jonathan Taylor and four touchdowns on the ground and one receiving.

Josh Allen has passed for 2,811 yards with 21 touchdowns and eight interceptions. The leading rusher for Buffalo is Devin Singletary with 415 yards and two touchdowns, while the leading receiver is Stefon Diggs with 773 yards and six touchdown receptions. On defense, safety Jordan Poyer is the leading tackler with 56 and defensive end Greg Rousseau has a team-high 3.5 quarterback sacks.

New Orleans dropped to 5-5 following a 40-29 loss to the Philadelphia Eagles on Sunday. The Saints are second in the NFC South 1 ½ games behind first place Tampa Bay. The Saints gave up 380 yards of total offense to Philadelphia, while gaining 323 yards of total offense but turned the ball over three times. New Orleans has lost three straight.

Trevor Siemian has passed for 920 yards with eight touchdowns and two interceptions. Running back Alvin Kamara has 530 yards and three touchdowns to lead the Saints, while Deonte Harris is the leading receiver with 418 yards and two touchdown receptions. On defense, linebacker Demario Davis is the leading tackler with 66 and defensive and Marcus Davenport is the leader in quarterback sacks with 5.5.

Recent Betting Trends

  • Buffalo is 7-3 ATS in its last 10 on the road
  • The OVER has cashed in 7 of the Bills last 10 on the road
  • New Orleans is 3-7 ATS in its last 10 versus an opponent with a winning record
  • The OVER has cashed in each of the Saints last 4

Free NFL Pick:

Buffalo Bills -4

Buffalo is coming off a disappointing loss to Indianapolis and fell out of first place in the AFC East. The Bills will be hot under the collar on Thanksgiving night when visiting the New Orleans Saints, who are playing short-handed with quarterback Jameis Winston out and wide receiver Michael Thomas still on the shelf. Final Score Prediction, Buffalo Bills win and cover ATS 27-17.

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