Buffalo Bills at New Orleans Saints 11/25/21 - NFL Picks & Predictions

The Buffalo Bills visit Caesars Superdome in New Orleans, Louisiana on Thanksgiving Night to play the New Orleans Saints.  Buffalo is 6-4 and second in the AFC East, a half-game behind New England following a 41-15 loss to the Indianapolis Colts on Sunday. Buffalo gained 307 yards of total offense and committed four turnovers, The Bills defense gave up 185 yards rushing to Jonathan Taylor and four touchdowns on the ground and one receiving.

Josh Allen has passed for 2,811 yards with 21 touchdowns and eight interceptions. The leading rusher for Buffalo is Devin Singletary with 415 yards and two touchdowns, while the leading receiver is Stefon Diggs with 773 yards and six touchdown receptions. On defense, safety Jordan Poyer is the leading tackler with 56 and defensive end Greg Rousseau has a team-high 3.5 quarterback sacks.

New Orleans dropped to 5-5 following a 40-29 loss to the Philadelphia Eagles on Sunday. The Saints are second in the NFC South 1 ½ games behind first place Tampa Bay. The Saints gave up 380 yards of total offense to Philadelphia, while gaining 323 yards of total offense but turned the ball over three times. New Orleans has lost three straight.

Trevor Siemian has passed for 920 yards with eight touchdowns and two interceptions. Running back Alvin Kamara has 530 yards and three touchdowns to lead the Saints, while Deonte Harris is the leading receiver with 418 yards and two touchdown receptions. On defense, linebacker Demario Davis is the leading tackler with 66 and defensive and Marcus Davenport is the leader in quarterback sacks with 5.5.