Arizona Cardinals at Cleveland Browns 10/17/21 - NFL Picks & Predictions

On Sunday, the Arizona Cardinals visit FirstEnergy Stadium in Cleveland, Ohio to play the Cleveland Browns. Arizona remained perfect on the season, improving to 5-0 after defeating the San Francisco 49ers 17-10. Arizona's defense held San Francisco to 338 yards of total offense and the Cardinals were led by quarterback Kyler Murray with 239 yards and one touchdown. Arizona is the only undefeated team remaining in the NFL.

Kyler Murray has passed for 1,512 yards with 10 touchdowns and four interceptions. The Cardinals signal-caller has been sacked 10 times. Chase Edmonds is the leading rusher with 270 yards while James Conner has 201 yards rushing and five touchdowns. DeAndre Hopkins is the leading receiver with 312 yards and four touchdown receptions. On defense, safety Budda Baker has a team-high 36 tackles and linebacker Chandler Jones is the leader in quarterback sacks with 5.0.

Cleveland fell to 3-2 following a 47-42 loss to the Los Angeles Chargers on Sunday. Cleveland's defense gave up 493 yards of total offense to the Chargers and the Browns gained 531 yards of total offense. Quarterback Baker Mayfield passed for 305 yards with two touchdowns and running back Nick Chubb rushed for 161 yards and one touchdown. However, Cleveland could not hold off the Chargers late, as the Browns gave up two Chargers’ touchdowns in the final 3:15 of the game.

Baker Mayfield has passed for 1,240 yards with four touchdowns and two interceptions. The Browns signal-caller has been sacked 13 times. Nick Chubb is the leading rusher with 523 yards and four touchdowns, while the leading receiver is David Njoku with 260 yards and one touchdown reception. On defense, linebacker Jeremiah Owusu-Koramoah is the leading tackler with 21 and defensive end Myles Garrett is the leader in quarterback sacks with 7.0.