St. Louis Cardinals at San Diego Padres 9/21/22 - MLB Picks & Predictions

Last Updated: 09/20/2022 at 10:57 PM ET

St. Louis Cardinals at San Diego Padres 9/21/22 - MLB Picks & Predictions

The St. Louis Cardinals continue a road trip Wednesday night in San Diego for game two of three against the San Diego Padres. St. Louis comes into Wednesday 26 games above .500 after a 3-0 loss for the Cincinnati Reds ended a 3 game win streak. Jordan Montgomery got the start for the Cardinals giving up three runs on seven hits across 5.1 innings of work leading to the loss. The St. Louis bullpen pitched well however allowing no runs on three hits over the final three-point two innings of the game.

Offensively St. Louis has played well this season carrying a combined 2.54 batting average to go along with 713 total runs scored on the year. Paul Goldschmidt leads the way for St. Louis with a .322 batting average to go along with a team high 35 home runs and 112 RBIs, while Nolan Arenado supplies the other power to the Cardinals lineup with a .296 batting average and a second best 29 long balls this year.

The San Diego Padres go back home Wednesday night 15 games over .500 riding a 3 game win streak after a sweep over Arizona. Yu Darvish dominated on the mound for San Diego allowing no runs on one hit across six innings to pick up the victory. The San Diego bullpen closed things out allowing only one run on three hits over the final three innings.

Offensively San Diego hit the ball well with eight hits in 32 at bats but went only 1-4 with runners in scoring position to leave six men on base. Juan Soto and Manny Machado led the way for the San Diego offense combining to go 4-8 from the plate to drive in two runs each.

These are two of the better teams in the National League as each will continue to jostle for playoff position. Look for St. Louis to use the hotter line-up and better pitcher Wednesday night on the road. Take the Cardinals to do enough in San Diego to pick up the underdog victory. Final Score Prediction, St. Louis wins 5-1.

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