San Francisco Giants at San Diego Padres 9/22/21 - MLB Picks & Predictions

Last Updated: 09/21/2021 at 10:17 PM ET

The San Francisco Giants play the second game of a three-game series on the road Wednesday against the San Diego Padres. San Francisco is 97-53 and lost to the Atlanta Braves 3-0 on Sunday. The Giants were off on Monday and San Francisco's lead at the top of the National League West has been reduced to just one game over the second-place Los Angeles Dodgers.

Brandon Crawford is batting .299 with 81 RBIs, 131 hits and an on base percentage of .373 to lead San Francisco in each category. First baseman Brandon Belt is the leader in home runs with 26.  The San Francisco Giants have not yet announced their starting pitcher for Wednesday’s second game of a three-game series on the road against the San Diego Padres.

San Diego is 76-73 following an 8-7 loss to the St Louis Cardinals on Sunday. The Padres did not play on Monday but have lost three straight and eight of the last 10. The Padres are third in the National League West 20 ½ games behind the first-place Giants and more importantly San Diego is four games behind St Louis for the second and final spot in the NL wildcard race. 

Fernando Tatis Jr with a batting average of .285, 39 home runs and an on-base percentage .368 leads San Diego in each category. Third baseman Manny Machado has 93 RBIs and 146 hits to lead the Padres in both. San Diego has not yet released the name of its starting pitcher for Wednesday's second game of a three-game series at home against San Francisco.

San Francisco has struggled against San Diego losing seven of the last 10 played at San Diego's Petco Park. The Padres are in need of victories each time out as San Diego is battling for a National League wild-card, while the Giants are trying to fight off the Los Angeles Dodgers for the NL West Title. However, the Giants have lost three of the last five overall. Final Score Prediction, San Diego Padres win 7-3

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