San Francisco Giants at San Diego Padres 9/21/21 - MLB Picks & Predictions

Last Updated: 09/20/2021 at 10:16 PM ET

On Tuesday, the San Francisco Giants open a three-game series on the road against the San Diego Padres. San Francisco is 97-53 following a 3-0 loss to the Atlanta Braves on Sunday. The Giants have lost three out of the last five but remain in first place in the National League West with a one-game lead over the Los Angeles Dodgers.

Shortstop Brandon Crawford is batting .299 with 81 RBIs, 131 hits and an on-base percentage of .373 to lead San Francisco in each category. First baseman Brandon Belt is the leader in home runs with 26. On Tuesday, San Francisco will send ace Kevin Gausman to the mound. The right-hander is 14-6 with an ERA of 2.78, 208 Ks and 49 BBs.

San Diego dropped to 76-73 following an 8-7 loss to the St. Louis Cardinals on Sunday. The Padres were swept by St. Louis in their three-game series over the weekend. San Diego has lost eight of the last ten and are 3 ½ games behind the St. Louis Cardinals for the second and final wild card berth in the National League.

Fernando Tatis Jr is batting .285 to lead San Diego and the shortstop has 39 home runs and an on-base percentage of .368 to lead the Padres in both. Third baseman Manny Machado has 93 RBIs and 146 hits to lead San Diego in each. On Tuesday, San Diego will send Joe Musgrove to the mound. The right-hander is 11-9 with an ERA of 2.99, 184 Ks and 48 BBs.

While the OVER is a solid choice here, the play is the Padres. San Diego has won three of starting pitcher Joe Musgrove’s last four starts and the right-hander has allowed a combined eight runs on 19 hits across 25 ⅓ innings in the four outings that included a victory over San Francisco last Wednesday. The Giants have lost seven of the last 10 in San Diego. Final Score Prediction, San Diego Padres win 7-5.

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