San Francisco Giants at Cleveland Guardians 4/17/22 - MLB Picks & Predictions

Last Updated: 04/16/2022 at 10:22 PM ET

San Francisco Giants at Cleveland Guardians 4/17/22 - MLB Picks & Predictions

The San Francisco Giants complete a three-game interleague series on the road Sunday against the Cleveland Guardians. San Francisco is 5-2 following its 4-1 victory over Cleveland in the opening game of the series on Friday. The Giants are tied for first place in the National League West with Colorado and Los Angeles, one game ahead of the San Diego Padres. San Francisco has won each of its last three.

First baseman Brandon Belt is batting .368 to lead San Francisco and has team highs in home runs with two, hits with seven and on base percentage at .500. Shortstop Thairo Estrada is the leader in RBIs with four. On Sunday, the San Francisco Giants will send Alex Wood to the mound. The left-hander is 0-0 with a 4.15 ERA, 6 Ks and 1 BBs.

Cleveland dropped to 4-3 following its loss to San Francisco on Friday. The loss snapped Cleveland's four-game winning streak. Cleveland is second in the American League Central just one game behind the first place Chicago White Sox. The Guardians are first in baseball in runs scored with 46 and lead the majors in team batting average at .286.

Shortstop Owen Miller is batting .522 to lead Cleveland. Third baseman Jose Ramirez is leading Cleveland in home runs with three, RBIs with 14 and hits with 13. Center fielder Steven Kwan is the leader in on-base percentage at .606. On Sunday, Cleveland will send Aaron Civale to the mound. The right-hander is 0-0 with a 5.40 ERA, 3 Ks and 3 BBs.

Cleveland will defeat San Francisco on Sunday in the final game of this series, but the play here is UNDER. The UNDER has cashed in 10 of the last 14 played between the two and in each of the last four played between the two in Cleveland. San Francisco is second in baseball in team ERA at 2.39, while Cleveland it is ninth in team ERA at 2.90 and holds opponents to a batting average of .203. Final Score Prediction, Cleveland Guardians win but our best play is UNDER 4-2.