San Francisco Giants at Cleveland Guardians 4/15/22 - MLB Picks & Predictions

The San Francisco Giants open a three-game interleague series on the road Friday with the Cleveland Indians. San Francisco improved to 4-2 following its 2-1 victory over the San Diego Padres on Wednesday. San Francisco won two out of three against the Padres and the Giants are second in the National League West, a half-game behind the first place Colorado Rockies. San Francisco was off on Thursday.

Brandon Belt is batting .438 to lead San Francisco and the first baseman has team highs in home runs with two, hits with seven and on-base percentage at .526. Thairo Estrada is the leader in RBIs with four. On Friday, San Francisco will send Carlos Rodon to the mound. The left-hander is 0-0 with a 1.80 ERA, 12 Ks and 2 BBs.

Cleveland improved to 4-2 following its 7-3 victory over the Cincinnati Reds on Wednesday. The Guardians swept Cincinnati in a short two-game interleague series after winning the first 10-5 on Monday. Cleveland is second in the American League Central, trailing the first place Chicago White Sox by a half-game. Cleveland has won each of its last four after opening the season with two consecutive losses.

Stephen Kwan is batting .526 to lead Cleveland and the center fielder has a team-high .655 on-base percentage. Third baseman Jose Ramirez is the leader in home runs with three, RBIs with 14 and hits with 12. On Friday, the Cleveland Guardians will send Zach Plesac to the mound. The right-hander is 0-0 with a 0.00 ERA, 3 Ks and 0 BBs.