San Diego Padres at St. Louis Cardinals 6/1/22 - MLB Picks & Predictions

Last Updated: 05/31/2022 at 11:52 PM ET

San Diego Padres at St. Louis Cardinals 6/1/22 - MLB Picks & Predictions

Busch Stadium will play host to a Wednesday afternoon MLB meeting between the San Diego Padres and the St. Louis Cardinals. The Padres (30-19) have won 17 of their first 26 road games and trail Los Angeles by 3.5 games for first place in the NL West Division. Last night, San Diego OF Trent Grisham hit a two-run blast during a 3-2 road loss against St. Louis in ten innings.

Thirty-five year old Yu Darvish (4-2 3.76 ERA) will take the mound for the Padres in this matchup. Last time out, Darvish gave up two runs in six plus innings during a 2-1 home loss versus Milwaukee.

The St. Louis Cardinals have won seven of their last ten games and trail NL Central Division leading by 3.5 games. On Tuesday, veteran DH Albert Pujols came through with a walk-off sacrifice fly that scored Tommy Edman. SP Adam Wainwright fanned ten batters across seven shutout innings and did not factor in the decision for the Cardinals (28-21).

The Cardinals will counter with twenty-seven year old righty Dakota Hudson (3-2 3.22 ERA) in the series finale. In his last start, Hudson fired four plus shutout frames during a 4-2 home victory versus Milwaukee.

St. Louis OF Tyler O’Neill (shoulder) is currently on the 10-day injured list and is still experiencing discomfort when throwing. Through 49 games, San Diego ranks 23rd in OPS and 15th in runs scored. For the season, St. Louis ranks 10th in OPS and 6th in runs scored. Take the Padres to win on the road. Final Score Prediction, San Diego Padres win 5-3.