San Diego Padres at San Francisco Giants 5/21/22 - MLB Picks & Predictions

Last Updated: 05/21/2022 at 7:42 AM ET

San Diego Padres at San Francisco Giants 5/21/22 - MLB Picks & Predictions

NL West Division rivals will clash on Saturday afternoon, when the San Diego Padres and the San Francisco Giants continue their weekend series from Oracle Park. The Padres (25-14) have won 15 of their first 22 road games and trail first place Los Angeles by 1.5 games. Last night, San Diego 3B Manny Machado collected three hits and scored a pair of runs during an 8-7 road victory in ten innings.

Twenty-nine year old righty Joe Musgrove (4-0 2.20 ERA) is making a strong case for an All-Star appearance. The Padres have won Musgrove’s last five starts and he has allowed just nine earned runs over his last 32 plus frames.

The San Francisco Giants have dropped consecutive games and have fallen four games off the pace in the NL West Division race. During Saturday's home loss, San Francisco went 2-for-8 with runners in scoring position and left nine men on base. Darin Ruf homered twice and scored three runs for the Giants (22-16).

Twenty-nine year old southpaw Carlos Rodon (4-2 3.49 ERA) will head to the hill for the Giants in this contest. Last time out, Rodon was tagged for eight runs in three plus innings during an ugly 15-6 road loss against St. Louis.

San Diego SS Fernando Tatis Jr. (wrist) Is working out at the team’s spring training facility and is expected to make his season debut next month. Through 39 games, San Diego ranks 21st in OPS and 11th in runs scored. For the season, San Francisco ranks 7th in OPS and 3rd in runs scored. Take the Padres to win on the road. Final Score Prediction, San Diego Padres win 5-3.