Cleveland Guardians at San Diego Padres 8/24/22 - MLB Picks & Predictions

Last Updated: 08/24/2022 at 10:16 AM ET

Cleveland Guardians at San Diego Padres 8/24/22 - MLB Picks & Predictions

On Wednesday, the Cleveland Guardians complete a two-game interleague series on the road with the San Diego Padres. Cleveland is 64-56 and was defeated by the Chicago White Sox 2-0 on Saturday. Cleveland's game scheduled on Sunday to complete a series with the White Sox was postponed. The Guardians are first in the American League Central, two games ahead of the second-place Minnesota Twins.

Second baseman Andres Gimenez is batting .309 to lead Cleveland and has a team high .374 on-base percentage. Third baseman Jose Ramirez is the leader in home runs with 23 and RBIs with 99, while shortstop Amed Rosario is the leader in hits with 133. On Wednesday, the Cleveland Guardians will send Cal Quantrill to the mound. The right-hander is 9-5 with a 3.77 ERA, 88 Ks and 37 BBs.

San Diego improved to 68-56 following its 2-1 victory over the Washington Nationals on Sunday. Josh Bell hit a home run for the second consecutive game in Sunday's victory. The Padres have won two straight and are second in the National League West but a distant 17 ½ games behind the first-place Los Angeles Dodgers.

Third baseman Manny Machado is batting .302 with 22 home runs, 76 RBIs, 131 hits and an on-base percentage of .372 to lead San Diego in each category. Jake Cronenworth is second in RBIs with 63. On Wednesday, the San Diego Padres will send Yu Darvish to the mound. The right-hander is 10-7 with a 3.39 ERA, 147 Ks and 27 BBs.

Cleveland has won six of the last seven on the road and the Guardians have won 10 of the last 14 overall. San Diego has struggled versus opponents with a winning record, losing four of the last five. San Diego starting pitcher Yu Darvish has been hit hard in each of the last two outings allowing seven runs on 12 hits across 14 ⅓ innings resulting in a pair of losses for San Diego. The Padres have lost four of Darvish’s last five starts. Final Score Prediction, Cleveland Guardians win 6-3.

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