Reds vs Cardinals Picks and Prediction – 6/21/2025

Busch Stadium will play host to a Saturday afternoon MLB afternoon MLB clash between the Cincinnati Reds and the St. Louis Cardinals. Be ready for the baseball season with all of our MLB predictions. The Reds (39-37) are a game below .500 on the road and are 6.5 games off the pace in the NL Central Division race. Last night, Cincinnati batters were limited to four hits during a 6-1 road loss against St. Louis. 

Thirty-eight year old southpaw Wade Miley (1-0 6.75 ERA) will make his third start of the year for the Reds. Last time out, Miley (5 IP) allowed two runs and struck out five batters during an 8-4 road victory against Detroit. 

The St. Louis Cardinals are riding a four-game winning streak and are 4.5 games behind Chicago for the top spot in the NL Central Division. During Friday’s home victory, St. Louis SS Masyn Winn went 2-for-5 with a run scored and an RBI. SP Andre Pallante (5-3) fired six shutout frames to earn the win for the Cardinals (41-35), who improved to 23-14 at home. 

Veteran right-hander Sonny Gray (7-2 3.84 ERA) is continuing to pitch well for the Cardinals at age thirty-five. Through 79 plus innings, Gray has retired 85 batters by strikes and owns a solid 1.18 WHIP.

Cincinnati OF Austin Hays (foot) resumed a running progression on Thursday and hopes to return by the end of the month. Through 76 games, Cincinnati ranks 11th in OPS and 8th in runs scored. For the season, St. Louis ranks 13th in OPS and 7th in runs scored. Take the over. Final Score Prediction, St. Louis Cardinals win 8-3.