Chicago White Sox at Tampa Bay Rays 8/21/21 - MLB Picks & Predictions

Last Updated: 08/20/2021 at 11:50 PM ET

Chicago White Sox at Tampa Bay Rays 8/21/21 - MLB Picks & Predictions

Division leaders will clash at Tropicana Field, when the Chicago White Sox take on the Tampa Bay Rays. The White Sox (72-52) are two games above .500 on the road and hold a comfortable 11.5 game lead for first place in the AL Central Division. Last night, All-Star SS Tim Anderson homered and scored four runs to spark Chicago to a 7-5 road victory against Tampa Bay in 11 innings.

2015 AL Cy Young Award winner Dallas Keuchel (8-6 4.48 ERA) will take the ball for the White Sox on Saturday. In his last start, Keuchel allowed two runs in five innings during a 5-2 home victory versus Oakland.

The Tampa Bay Rays have won 39 of their first 62 home games and lead New York by four games in the AL East Division race. On Friday, Tampa Bay RP J.T. Chargois served up the game-tying home run in the ninth inning and blew his third save. OF Austin Meadows had two hits and drove in a pair of runs in a losing effort for the Rays (75-48).

Rookie right-hander Luis Patino (2-3 4.73 ERA) will make his 11th career major league start for the Rays. Last time out, Patino allowed two runs and lasted just three innings during a 5-4 road loss against Minnesota.

Chicago SP Carlos Rodon is dealing with left shoulder fatigue and hopes to start next week against Toronto. Through 123 games, Chicago ranks 8th in OPS and 7th in runs scored. For the season, Tampa Bay ranks 11th in OPS and 1st in runs scored. Take the White Sox to win on the road. Final Score Prediction, Chicago White Sox win 6-3.