White Sox vs Pirates Picks and Prediction – 7/18/2025

Scenic PNC Park will play host to a Friday evening MLB interleague battle between the Chicago White Sox and the Pittsburgh Pirates. Be ready for the baseball season with all of our MLB predictions. The White Sox (32-65) have dropped 36 of their first 47 road games and own the worst overall record in the American League. On Sunday, Chicago OF Andrew Benintendi went 3-for-5 with a solo shot during a 6-5 home loss versus Cleveland in ten innings. 

Twenty-four year old righty Jonathan Cannon (3-7 4.44 ERA) will take the mound for the White Sox in this matchup. In his last start, Cannon (5 IP) allowed two runs and fanned five batters during a 5-4 home victory versus Cleveland. 

The Pittsburgh Pirates are five games above .500 at home and are buried in the NL Central Division basement. Last time out, OF Tommy Pham homered and Pittsburgh snapped an eight-game losing streak with a 2-1 road victory against Minnesota. SP Mitch Keller allowed one run across six solid frames and did not factor in the decision for the Pirates (39-58). 

Pittsburgh manager Don Kelly will give the nod to talented lefty Bailey Falter (6-4 3.79 ERA) on Friday. In ten home starts, Falter is 5-1 with a 3.25 and has limited the opposition to four long balls across 52 plus frames. 

Chicago SP Davis Martin (forearm) will make a rehab start sometime this week and hopes to rejoin the rotation later this month. Through 97 games, Chicago ranks 30th in OPS and 28th in runs scored. For the season, Pittsburgh ranks 29th in OPS and 30th in runs scored. Take the under. Final Score Prediction, Pittsburgh Pirates win 4-2.