Chicago White Sox at Detroit Tigers 9/22/21 - MLB Picks & Predictions

Last Updated: 09/21/2021 at 10:08 PM ET

In Wednesday afternoon MLB action, the Chicago White Sox will battle the Detroit Tigers from Comerica Park. The White Sox (85-66) are three games below .500 on the road and are on the verge of clinching the AL Central Division title. Last night, Chicago OF Luis Robert had two hits and drove in a pair of runs during a 5-3 road loss against Detroit.

Talented right-hander Reynaldo Lopez (3-3 3.00 ERA) will take the mound for the White Sox in this matchup. Last time out, Lopez was tagged for seven runs (6 ER) in four innings during a 9-3 home loss versus Los Angeles.

The Detroit Tigers have won four straight games and have played well for first year manager A.J. Hinch. During Tuesday’s home victory, OF Daz Cameron collected three hits and scored a pair of runs to spark the Detroit offense. SP Tyler Alexander allowed two runs in five innings and did not factor in the decision for the Tigers (74-78).

The Tigers will counter with former number one overall draft pick Casey Mize (7-8 3.64 ERA) on Wednesday. Through 143 plus innings, Mize has struck out 111 batters and owns a solid 1.14 WHIP.

Detroit closer Gregory Soto has been placed on the 10-day injured list with a fractured left ring finger. Through 151 games, Chicago ranks 7th in OPS and 6th in runs scored. For the season, Detroit ranks 24th in OPS and 19th in runs scored. Take the Tigers to win at home. Final Score Prediction, Detroit Tigers win 6-3.

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