White Sox vs Reds Picks and Prediction – 5/13/2025

In Tuesday night MLB interleague action, the Chicago White Sox will travel to the Great American Ball Park to take on the Cincinnati Reds. Be ready for the baseball season with all of our MLB predictions. The White Sox (12-29) have dropped 17 of their first 20 road games and own the worst overall record in the American League. On Sunday, DH Tim Elko crushed a three-run shot in the sixth inning to lift Chicago to a 4-2 home victory versus Miami. 

Twenty-four year old righty Jonathan Cannon (2-4 4.09 ERA) will head to the hill for the White Sox in this contest. Last time out, Cannon (6 IP) gave up nine hits and two runs during a 2-1 road loss against Kansas City. 

The Cincinnati Reds are a game below .500 at home and are 3.5 games off the pace in the NL Central Division race. On Sunday, Cincinnati batters were limited to a pair of hits and were retired by strikes 12 times during a 6-0 road loss against Houston. SP Chase Petty (0-2) was tagged for four runs in three innings and took the loss for the Reds, who fell to 20-22 on the year. 

Twenty-five year old southpaw Andrew Abbott (2-0 2.25 ERA) is quietly pitching well for the Reds. Through 24 innings, Abbott has allowed three home runs and fanned 31 batters while posting a solid 1.17 WHIP.

Cincinnati SP Hunter Greene has landed on the 15-day injured list with a Grade 1 right groin strain. Through 41 games, Chicago ranks 30th in OPS and 28th in runs scored. For the season, Cincinnati ranks 13th in OPS and 8th in runs scored. Take the over. Final Score Prediction, Cincinnati Reds win 7-5.