Chicago White Sox at Cincinnati Reds 5/5/21 - MLB Picks & Predictions
Last Updated: 05/04/2021 at 9:56 PM ET

The Chicago White Sox conclude a two-game interleague series on the road Wednesday against the Cincinnati Reds. Chicago is 15-12 following a 5-0 loss to the Cleveland Indians on Sunday. The White Sox were off on Monday. Chicago also lost center fielder Luis Robert, who tore his hip flexor and could be out between 12 and 16 weeks. The White Sox are second in the American League Central One game behind the first-place Kansas City Royals.
Yermin Mercedes is batting .395 to lead Chicago and has team highs in hits with 34 and on-base percentage at .435. First baseman Jose Abreu is the leader in home runs five and RBIs with 19. Chicago has hit 24 home runs in its first 27 games. On Wednesday, Chicago will send Dallas Keuchel to the mound. The lefthander is 1-1 with an ERA of 4.65, 16 Ks and 11 BBs.
Cincinnati was idle on Monday and the Reds improved to 13-14 with a 13-12 victory over the Chicago Cubs on Sunday. Nick Castellanos hit an RBI single in the 10th inning to knock in the winning run for the Reds. Cincinnati won two of three games over the weekend against the Cubs and the Reds are third in the National League Central three games behind both the Milwaukee Brewers and St Louis Cardinals.
Jesse Winker is batting .365 to lead Cincinnati and has a team-high .419 on-base percentage. Right fielder Nick Castellanos is leading Cincinnati in home runs with nine, RBIs with 20 and hits with 35. Cincinnati has hit 43 home runs in its first 27 games. On Wednesday, Cincinnati will send Sonny Gray to the mound. The right-hander is 0-2 with an ERA of 5.93, 23 Ks and 11 BBs.
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Chicago will pick up a victory on the road Wednesday against Cincinnati, but the play here is OVER. The OVER has cashed in 19 of Cincinnati's last 27 overall and in six of the last seven that Cincinnati has played at home. The White Sox are third in baseball in team batting average at .257 and have scored the seventh most runs with 134. Cincinnati is 26th in team ERA at 4.97. Final Score Prediction, Chicago White Sox win but our best play is OVER 7-4.