Chicago Cubs at Pittsburgh Pirates 9/22/22 - MLB Picks & Predictions

The Chicago Cubs head to Pittsburgh on Thursday to take on the Pirates after playing in Miami on Wednesday night. The Cubs are 3rd in the NL Central and have won five of their last ten games. Chicago is averaging 4 runs per game which ranks 23rd in the league. Ian Happ leads the Cubs with 142 hits on the season. 

Hayden Wesneski will make the start on the mound for the Cubs. Wesneski is 1-1 on the season with 15.2 innings pitched. Wesneski has 18 strikeouts and carries a 2.30 ERA. Wesneski pitched 7 innings in his last start allowing 1 run and 3 hits. 

The Pittsburgh Pirates remain home on Thursday after playing in New York on Wednesday. The Pirates have won four of their last ten games and are last in the NL Central. Pittsburgh is led by Bryan Reynolds who has 129 hits and 24 home runs. The Pirates carry a losing 28-43 home field record. 

Mitch Keller will make his 27th start on the mound for the Pirates. Keller is 5-11 on the season with 143 innings pitched. Keller has 121 strikeouts and carries a 4.03 ERA. Keller pitched 6 innings in his last start allowing 3 runs and 5 hits. The Pirates lost to the Cubs in their last meeting 4-2 back in July.