Diamondbacks vs Padres Picks and Prediction – 7/10/2025

This Wednesday, Brandon Pfaadt and the Arizona Diamondbacks face off against Dylan Cease and the San Diego Padres in a rematch of Monday’s 6-3 Arizona victory. Get our free MLB Picks all season long! The Diamondbacks backs look to stay hot, while the Padres will try to bounce back and even the short series at Chase Field.

Pfaadt pitched well in his last start and is steadily developing into a dependable option for Arizona’s rotation. His fastball-slider combo continues to challenge opposing hitters, and keeping walks down will be key. Offensively, the Diamondbacks capitalized on clutch hits Monday and have been more consistent lately with runners in scoring position.

Cease, meanwhile, will look to rebound after giving up early damage in his last outing. He possesses elite strikeout stuff but has occasionally struggled with command. The Padres will need him to go deeper into the game, especially with their bullpen logging significant innings recently. San Diego’s offense, led by several power threats, must get going early to support Cease.

This is a pivotal midseason matchup as both sides are hovering around .500, both with playoff aspirations. Whichever team controls the tempo early will have the upper hand.

Arizona holds the edge with recent momentum and a more stable starter. Pfaadt limits damage while the Diamondbacks manufacture just enough run support. Expect players like Eugenio Suarez to step up when it matters the most. Take the Arizona Diamondbacks grab the win and to get back up to .500. Final Score Prediction, Arizona Diamondbacks win 4-3.