Arizona Diamondbacks at Chicago Cubs 5/20/22 - MLB Picks & Predictions

Last Updated: 05/20/2022 at 9:37 AM ET

The Friday MLB schedule will get underway with a matinee between the Arizona Diamondbacks and the Chicago Cubs from Wrigley Field. The Diamondbacks have dropped eight of their previous ten games and are trying to climb out of the NL West Division cellar. 1B Christian Walker leads the Diamondbacks with nine home runs and 18 runs batted in.

Twenty-four year old righty Humberto Castellanos (2-1 4.15 ERA) will make his seventh start for the Diamondbacks. Last time out, Castellanos gave up two runs in five plus innings during a 3-2 home loss versus Chicago.

The Chicago Cubs were majors sellers at last season's trade deadline and are focused on rebuilding around their young talent. Last week the Cubs were able to take two out of three against the Diamondbacks in the desert. This week rookie 2B Christian Morel hit a home run in his first major league at bat and 3B Patrick Wisdom leads Chicago with six long balls.

Chicago manager David Ross will turn to veteran right-hander Kyle Hendricks (2-3 4.03 ERA) on Friday. In his last start, Hendricks allowed one run across five plus frames during a 4-2 road victory against Arizona. 

Chicago 2B Nico Hoerner (ankle) has resumed baseball activities and should return early next month. Through 39 games, Arizona ranks 23rd in OPS and 23rd in runs scored. For the season, Chicago ranks 17th in OPS and 19th in runs scored. Take the Diamondbacks to win on the road. Final Score Prediction, Arizona Diamondbacks win 4-3.

Download the Picks and Parlays Mobile App

Get A free VIP Pick Daily!