Ohio State at Indiana 10/23/21 - College Football Picks & Predictions

By: Zack |

Last Updated: 10/22/2021 at 1:21 PM ET

The No. 6 ranked Ohio State Buckeyes visit Memorial Stadium in Bloomington, Indiana on Saturday to play the Indiana Hoosiers. Ohio State had a bye in Week 7 and improved to 5-1 overall with a 66-17 victory over the Maryland Terrapins in Week 6. Ohio State gained 598 yards of total offense and held Maryland to 335 yards of total offense and forced the Terrapins into two turnovers. C.J. Shroud passed for 406 yards and five touchdowns.

CJ Stroud has passed for 1,699 yards with 18 touchdowns and three interceptions. The Buckeyes’ signal caller has been sacked only four times. TreVeyon Henderson is the leading rusher with 612 yards and nine touchdowns, while the leading receiver is Garrett Wilson with 546 yards and six touchdown receptions. On defense, safety Ronnie Hickman is the leading tackler with 50, while tackle Tyleik Williams is the leader in quarterback sacks with 4.0.

Indiana dropped to 2-4 overall and 0-3 in the Big Ten with a 20-15 loss at home to the Michigan State Spartans. Indiana held Michigan State to only 241 yards of total offense but the Hoosiers gained only 322 yards of total offense and turned the ball over three times. Indiana quarterback Jack Tuttle passed for 188 yards with two interceptions while running back Stephen Carr rushed for 53 yards and one touchdown. The leading receiver for Indiana was Ty Fryfogle with 65 yards. 

Backup quarterback Jack Tuttle playing in place of the injured Michael Penix Jr. has passed for 350 yards with one touchdown and three interceptions. The leading rusher for Indiana is Stephen Carr with 439 yards and four touchdowns, while the leading receiver is Ty Fryfogle with 337 yards and one touchdown reception. On defense, linebacker Cam Jones is the leading tackler with 35 and lineman Ryder Anderson has the team lead in quarterback sacks with 3.5. 

Ohio State will defeat Indiana on the road Saturday, but the play here is OVER. The OVER has cashed in each of the last four meetings between these two Big Ten rivals. In addition, the OVER has cashed in six of Ohio State's last eight played in the Big Ten and in 13 of Indiana's last 18 versus an opponent with a winning record. Ohio State is seventh in the nation in scoring with an average of 48.5 points per game. Final Score Prediction, Ohio State Buckeyes win but our best play is OVER 47-20.

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