Penn State vs USC Picks and Prediction – 2/12/2025

By: Jeremy O’Quinn |

Last Updated: 02/10/2025 at 8:39 PM ET

Penn State at USC 02/11/25 - NCAAB Picks & Predictions
Game Start: 2/12/2025, 2:00 AM UTC
Latest Odds: USC -4.5 ; O/U 151.5

Penn State vs USC Prediction

The Penn State Nittany Lions are heading to the Galen Center on Tuesday, where they will face the USC Trojans. Get the rest of our free college basketball picks here! The Nittany Lions come into Tuesday’s game with a 13-11 record which places them eighteenth in the Big Ten. The Nittany Lions are in the midst of a five game losing skid, most recently suffering a 78-54 loss to UCLA on Saturday. The Nittany Lions have been scoring 80.3 points per game on 47.7% shooting from the field and 33.9% from three. Penn State comes into this game with a 103.7 defensive rating.

The USC Trojans currently sit tenth in the Big Ten, entering this game with a 13-10 record. The Trojans have now dropped consecutive games, most recently suffering a 90-72 loss against Purdue on Friday. Wesley Yates erupted for 33 points in this game, while Isaiah Elohim added 11 points off the bench. USC is scoring 76.4 points per game on 47.7% shooting from the field and 34.2% from three. The Trojans have struggled on the defensive end, posting a 108.0 defensive rating.

Penn State vs USC Pick Analysis

Penn State is desperate to bring their force game losing skid to an end, while USC has lost two straight of their own heading into this game. Expect Penn State’s scoring to elevate in this game, leading them to a much needed win. Final score prediction, Nittany Lions win 80-78.

Our Free NCAA Basketball Pick for USC vs Penn State

Penn State Nittany Lions +164