Niagara vs Siena Picks and Prediction – 2/22/2025

By: Jeremy O’Quinn |

Last Updated: 02/20/2025 at 7:47 PM ET

Niagara at Siena 02/21/25 - NCAAB Picks & Predictions
Game Start: 2/22/2025, 12:00 AM UTC
Latest Odds: SIE -6.5 ; O/U 137.5

Niagara vs Siena Prediction

The Niagara Purple Eagles are heading to Draddy Gymnasium on Saturday, where they will face the Manhattan Jaspers. Get the rest of our free college basketball picks here! Niagara comes into this game with a 10-15 record which places them tenth in the Metro Atlantic Athletic. The Purple Eagles have dropped 7 of their last 10 games, most recently suffering an 84-83 loss to Mount St. Mary’s on Friday. The Purple Eagles are scoring 68.6 points per game on 45% shooting from the field and 35.2% from three. Niagara has struggled on the defensive end the season, posting a 109.1 defensive rating.

The Siena Saints have put together a 12-14 record which places them eighth in the Metro Atlantic Athletic. After dropping two straight games, the Saints would bounce back with an 80-73 victory over Sacred Heart on Sunday. Gavin Doty and Brenden Coyle each scored 22 points in their win over Sacred Heart. Siena is scoring 70.8 points per game on 42.8% shooting from the field and 33.0% from three. The Saints have been mediocre in the defensive end, sitting with a 106.9 defensive rating.

Niagara vs Siena Pick Analysis

The Saints are looking to build off a win over Sacred Heart, while Niagara looks to bounce back after a loss from Mount St. Mary’s. The Saints have been the better team on both sides of the floor, expect them to cover the -6.5 spread here. Final score prediction, Saints win 74-65.

Our Free NCAA Basketball Pick for Siena vs Niagara

Siena Saints -6.5