Mississippi vs Michigan State Picks and Prediction – 3/28/2025

On Friday, the 6th-seeded Ole Miss Rebels will play the 2nd-seeded Michigan State Spartans in the Sweet 16 of the NCAA tournament at State Farm Arena in Atlanta, Georgia. Ole Miss defeated 3rd-seeded Iowa State 91-78 on Sunday night in the second round. Sean Pedulla was the leading scorer for Ole Miss with 20 points. The Rebels led by 11 at the half and held off the Cyclones after the break. Keep updated on College Basketball with our expert college basketball picks.

Ole Miss shot 58.2% overall and 57.9% from 3-point territory. The Rebels committed just eight turnovers while forcing Iowa State into turning the ball over 15 times. Ole Miss used a balanced scoring attack as five players scored in double figures led by Pedulla. Jaemyn Brakefield came off the bench to score 19 points for the Rebels. The Rebels shot 76.2% from the free-throw line.

The Michigan State Spartans reached the Sweet 16 by defeating Bryant 87-62 in the first round followed by Sunday’s 71-63 victory over New Mexico in the second round. On Sunday, Jaden Akins scored 16 points to lead Michigan State, which included a 3-pointer that put the Spartans ahead for good. Michigan State's head coach Tom Izzo has now taken the Spartans to 16 Sweet 16’s.

Michigan State shot 44.4% overall and 26.7% from 3-point territory while allowing New Mexico to shoot 48.2% overall and 30.8% from 3.0 territory. The Spartans committed just 9 turnovers and outrebounded the Lobos 34-28. Three of five starters scored in double figures for the Spartans but Michigan State received very little help in scoring from the bench with just seven points.

The Michigan State Spartans have covered the number in 10 of the last 11 and will make it 11 out of 12 with a victory and cover on Friday in the Sweet 16 when facing the Ole Miss Rebels. During the regular season, Michigan State held opponents to an average of 67.2 points per game on 40.3% shooting overall and 27.9% from 3-point territory. In two NCAA tournament games, the Spartans have held opponents to an average of 62.5 points. Final Score Prediction, Michigan State Spartans win and cover ATS 75-69.