Iowa State vs Houston Picks and Prediction – 2/22/2025

By: David Anicetti |

Last Updated: 02/21/2025 at 9:45 PM ET

Iowa State at Houston 02/22/25 - NCAAB Picks & Predictions
Game Start: 2/22/2025, 7:00 PM UTC
Latest Odds: HOU -12.5 ; O/U 132.5

Iowa State vs Houston Prediction

On Saturday, the No. 8-ranked Iowa State Cyclones visit Fertitta Center in Houston for a Big 12 battle with the No. 5-ranked Houston Cougars. Iowa State is 21-5 overall and 11-4 in Big 12 play, three games behind first place. The Cyclones defeated Colorado 79-65 on Tuesday. Milan Momcilovic led Iowa State with 13 points. The Cyclones have won four straight. Keep updated on College Basketball with our college basketball picks.

Chris Jones leads Iowa State in scoring, averaging 17.2 points per game. Keshon Gilbert is second in scoring and the leader in assists, averaging 14.1 points and 4.5 assists per game. Joshua Jefferson is the leading rebounder, averaging 7.9 rebounds per game. Iowa State has five players who average double figures in scoring. The Cyclones score an average of 81.3 points per game.

The Houston Cougars look for a sixth consecutive win on Saturday when hosting Iowa State. Houston is 22-4 overall and a Big 12-leading 14-1. The Cougars beat Arizona State 80-65 on Tuesday night. LJ Cryer was the leading scorer for Houston with 18 points and Emanuel Sharp chipped in with 17 points. Houston has won five straight and 18 of the last 19.

LJ Cryer leads Houston in scoring, averaging 14.5 points per game and Emanuel Sharp is second with an average of 12.0 points per game. J’Wan Roberts is the leading rebounder, averaging 6.4 rebounds per game and Milos Uzan is the leader in assists, averaging 4.9 per game. Houston scores an average of 75.4 points per game, shooting 46.0% overall and 39.4% from 3-point territory.

Iowa State vs Houston Pick Analysis

The Houston Cougars will win and cover the number on Saturday when hosting the Iowa State Cyclones. Houston has covered the number in six of its last nine, while Iowa State has failed to cover the nut in five of its last seven. Houston leads the nation in points allowed at 57.7 per game and allows an average of only 38.3% shooting overall, which is fifth lowest in the country. Final Score Prediction, Houston Cougars win and cover ATS 67-54.

Our Free NCAA Basketball Pick for Houston vs Iowa State

Houston Cougars -12.5